Monograph
D07AA02 - Hydrocortisone |
Propably not porphyrinogenic |
PNP |
Rationale
Probably only insignificant absorption. Ligand to PXR. Substrate for CYPs 3A4, 3A7, 11 B2. Inducer and inhibitor (!) of CYP 3A4. Several references stating non-porphyrinogenicity.
Chemical description
Mild glucocorticoid 0.1 % ointment used in dermatology. Systemic exposure on application on large areas of the body. Glucocorticoid: South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: use. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe.
IPNet drug reports
Uneventful use reported in 8 patients with acute porphyria.
Similar drugs
References
Tradenames
Hydrocortison · Hydrocortison-vaselinecrème 
Cremicort · Hydrocortisone · Pannocort 
Calmiox · Dermosa Hidrocortisona · Hidrocisdin · Lactisona 
Hikomicron · Hydrocortison 
Hidrocortizon 
Sanadermil 
Boots Bite and Sting Relief Hydrocortisone · Boots Derma Care Hydrocortisone · Derma Care Hydrocortisone · Dermacort hydrocortisone · Dioderm · Efcortelan · Exe-Cort Hydrocortisone · Hc45 Hydrocortisone · Hydrocortisone · Lanacort · Mildison Lipocream · Pinewood Bites and Stings Relief · Skincalm Hydrocortisone Bite and Sting Relief · Zenoxone 
Hydrokortison · Mildison 
Hydrokortison · Mildison 
Dermocort · Hydrocort · Hydrocortisonum · Hydrokortyzon Allefin · Maxicortan 
Cortisedermyl · Cremicort · Pannocort · Soventol · Soventol Hydrocortisonacetat 
Hydrokortison · Mildison 
Hydrocortison · Hydrocortisone 
Hydrocortisone 
Hydrocortisone 
Hydrocortison 
Lergin