Monograph
D07AB01 - Clobetasone |
Not porphyrinogenic |
NP |
Rationale
Several references stating non- porphyrinogenicity of glucocorticoids.
Chemical description
Moderately strong Glucocorticoid ointment and creme 0.05 % used in skin treatment. Systemic exposure in application on large areas of the body. Glucocorticoid: South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: use. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
Tradenames
Emovate 
Emovate 
Clobavate · Clobetasone · Clobetasone 0.05% cream 50% in Aqueous cream · Clobetasone 0.05% cream 50% in White soft paraffin · Clobetasone 0.05% ointment 50% in Calamine and Coal tar ointment · Clobetasone 0.05% ointment 50% in White soft paraffin · Coal tar / Clobetasone · Eumovate · Eumovate Eczema and Dermatitis