The glucocorticoid and ASA components are stated in several references not to be porphyrinogenic. Probably only insignificant systemic exposure.

Strong glucocorticoid 0.5 mg/g in combination with acetylsalicylic acid. Ointment used in steroide sensitive dermatoses. Glucocorticoid : South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Acetylsalicylic acid: South African list: safe. Kalman, Bonkovsky: safe. Michael Moore’s list: safe. The Merck Manual: safe . Eales L: Porphyria and the dangerous lifethreatening drugs, S Afr Med 56:914, 1979: safe.

Uneventful use reported in 1 patient with acute porphyria.