Monograph
A04AA02 - Granisetron |
Propably not porphyrinogenic |
PNP |
Rationale
Substrate for CYPs 3A4 and 3A5. No data pointing to clinical CYP-induction. One reference: authorised.
Chemical description
Selective 5-HT-antagonist used as prophylaxis or treatment of postoperative nausea and nausea under chemotherapy ; 2-9 mg/d perorally or parenterally. Metabolized mainly by CYP 3A4. No instances of CYP-induction observed clinically. South African list: No data/avoid. French list: authorized
IPNet drug reports
Uneventful use reported in 2 patients with acute porphyria.
Similar drugs
References
Tradenames
Granisetron · Kytril · Sancuso 
Granisetron · Kytril · Sancuso 
Granisetron · Kytril · Sancuso 
Granegis · Granigen · Granisetron · Sancuso 
Grandise · Granisetron · Kytril · Pandiol · Sancuso 
Granegis · Granisetron · Granored · Sancuso 
Granisetron · Kytril 
Granisetron · Kytril · Sancuso 
Granisetron · Sancuso 
Granisetron · Sancuso 
Sancuso 
Sancuso 
Granem · Sancuso 
Granisetron · Kytril · Sancuso 
Granisetron · Sancuso 
Sancuso 
Granisetron · Kytril · Sancuso 
Kytril · Rasetron 
Granisetron · Kytril · Rasetron · Sancuso 
Sancuso 
Kytril · Sancuso · Sustol 
Granisetron