Monograph
N02BA51 - Acetylsalicylic Acid, Combinations Excl. Psycholeptics |
Not porphyrinogenic |
NP |
Rationale
Acetylsalicylic acid: Insignificant CYP 2C9 metabolism. Repeatedly experienced to be safe in acute porphyria. Several references consider it safe. Caffeine: Widely used as beverage, no observations of porphyrinogenic side effects.
Chemical description
Acetylsalicylic acid: Water soluble light analgesic, inhibitor of prostaglandin synthesis. Metabolized by conjugation with glycine. Acetylsalicylic acid: MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use EPI-list: safe South African list: use French list: use Kalman, Bonkovsky: safe Merck Index: safe Eales L: Porphyria and the dangerous life-threatening drugs. S Afr Med J 56:914,1979: safe. Thunell; patient inquiry: tolerated n=20)
IPNet drug reports
Uneventful use reported in 22 patients with acute porphyria.
Similar drugs
References
Tradenames
apc · Aspirine-C · Excedrin 
Aspirine Cafeine · Aspirine-C · Excedryn · Perdolan Compositum · Troc Comp 
Actron Compuesto · Acyflox · Aspirina · Aspirina c · Aspirina Plus · Cafiaspirina · Calmante Vitaminado Perezgimenez · Couldina Acido Acetilsalicilico · Excedite · Okaldol Cafeina · Okaldol Dispersables · Sedergine c 
Aspicont · Aspirin Plus c Forte · TABLETTA ANTIDOLORICA FoNo VIII. 
Algopirin · Antinevralgic · Aspaco · Aspirin Plus c · Aspirin Plus c Forte · Fascomit · Fasconal · Maxipirin c · Nevralgio 
Aspirin · Aspirin-C · Contra-Schmerz plus 
Alka-Seltzer · Alka-Seltzer XS · Anadin Extra · Anadin Original · Aspav · Aspirin Extra · Beechams Powders · Boots Aspirin and Codeine · Boots Aspirin Extra · Co-codaprin · Extra Power Pain Reliever · MigraMax · Original Phensic Aspirin · Paramed Extra Power Pain Control 
Treo · Triplo 
AntyGrypin · Ascalcin Plus · Aspirin C · Aspirin C Forte · Coffepirine · Dampiryna · Etopiryna · Etopiryna Kontrol · Excedrin MigraStop · FluControl Symptom · Gripex · Kopiryna · Maxipirin C · Migromin · Polopiryna C · Polopiryna C Plus · Przeziebienie i Grypa · Ultrapiryna C · Ultrapiryna Plus · Upsarin C 
Asperine Cafeine · Aspirine c · ass + c 
Treo · Triplo 
Finrexin · Ring · Treo 
Cephyl · Citramon Forte · Febrisan · Upsarin c 
Aspirin C · Citramon · Citramons forte · Upsarin C 
Aspirin · Zankaf 
Acetilsalicilna kislina / psevdoefedrin · Ascalcin · ASPIRIN forte · Aspirin plus C · Doulfar · Excedrinil · Fortalgin c