Substrate of CYP 2D6. Inhibitor of CYPs 2D6, 1A2, 2E1, 3A4. Several references state non-porphyrinogenicity (phenothiazines in general).

Low-dose phenothiazine neuroleptic used in manic and psychotic conditions Metabolized by CYP 2D6. No data indicating CYP-induction. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use (phenothiazines). Australian list: safe EPI-list: safe South African list: use French list: use (fluphenazine) Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe