Acute Porphyria Drugs

Monograph

R01AD08 - Fluticasone
Not porphyrinogenic
NP

Rationale
Probably insignificant systemic exposure. Several references stating non-porphyrinogenic metabolism of glucocorticoids.
Chemical description
Antiasthmatic antiinflammatory glucocorticoide, administered as inhalation powder (50 - 250 µg/dose). Systemic exposure about 16% of the taken dose. Rapidly metabolized by CYP 3A4 (within 3-4 hours). EPI-list: safe French list: authorized South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan's Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe
Similar drugs
Explore alternative drugs in similar therapeutic classes R01A / R01AD or go back.
References
Tradenames

Flixonase · Fluticason · Fluticasonpropionaat Flixonase · Otrivine Flixonase · Flonase · Fluticasona · Nasotricin Flixonase · Flutirin Flonase Flutinase Polynex · Nasofan Avamys · Boots Pharmacy Hayfever and Allergy · Coryen · Flixonase · Flixonase Nasule · Fluticasone 400microgram/unit dose nasal drops · Fluticasone propionate · Flutikaz · Nasofan · Nasofan Allergy · Pirinase Hayfever · Pirinase Hayfever Relief for Adults Flixonase · Flurhin · Fluticasonpropionat · Otrason Flixonase · Flurhin · Flutide · Flutikason · Otrason Fanipos · Flixonase · Flixonase Nasule · OtriAllergy Flixonase · Otrivine Anti-Allergie Otrason Flixonase · Flurhin · Nasofan Flixonase · Fluticasone Flixonase Flixonase · Fluticasone · Nasofan Flixonase · Flixonase ari · Flutikazonpropionat
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