Monograph
R03BA01 - Beclometasone |
Not porphyrinogenic |
NP |
Rationale
Inducer of CYP 3A5. Probably insignificant absorption. Several references stating non-porphyrinogenicity of glucocorticoids.
Chemical description
Halogenated corticosteroid in inhalation aerosol, used in treatment of asthma. Systemic exposure only of doses > 1 500 ug/24 h (adults) Used in porphyria ward (Sweden). glucocorticoids EPI-list: safe South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncans Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe
IPNet drug reports
Uneventful use reported in 12 patients with acute porphyria.
Similar drugs
References
Tradenames
Beclometason · Beclometasondipropionaat · Qvar · Soprobec 
Qvar 
Beclo-Asma · Becloforte · Becotide · Soprobec 
Beclometasone · Becotide · Clenil · Clenilexx · Prontinal 
Clenil jet · Soprobec 
Beclo · Qvar 
AeroBec 100 · AeroBec 50 · AeroBec Forte 250 · Asmabec 100 · Asmabec 250 · Asmabec 50 · Beclazone 100 · Beclazone 200 · Beclazone 250 · Beclazone 50 · Becloforte · Beclometasone · Beclometasone 100 · Beclometasone 200 · Beclometasone 400 · Beclu · Becodisks · Becotide · Becotide 100 · Becotide 200 · Becotide 50 · Clenil Modulite · Easyhaler Beclometasone · Filair 100 · Filair 50 · Filair Forte · Kelhale · Pulvinal Beclometasone Dipropionate · Qvar · Soprobec 
Aerobec · Beclomet · Beclometasondipropionat 
Aerobec · Beclomet 
Soprobec 
Qvar 
Aerobec · Beclomet 
Becloforte 
Becloforte · Becodisks · Becotide · Plibecot