Administered locally in the eye and systemic exposure is insignificant.

Fluorinated analog of prostaglandin F2-alpha.

Tafluprost eye drops reduce elevated intraocular pressure in open angle glaucoma and ocular hypertension.

Mean plasma tafluprost acid concentrations were below the limit of quantification of the bioanalytical assay (10 pg/mL) and hepatic exposure is therefore insignificant (SPC).

Tafluprost is a prodrug and is hydrolyzed to the pharmacologically active metabolite, tafluprost acid. Tafluprost acid is further metabolized by glucuronidation and beta-oxidation. CYP450 enzymes are not involved in the metabolism.