Monograph
V03AB35 - Sugammadex |
Propably not porphyrinogenic |
PNP |
Rationale
Sugammadex is not metabolized, but is excreted in unhanged form or as a complex.
Chemical description
Modified gamma cyclodextrin.
Therapeutic characteristics
Sugammadex is used for reversal of neuromuscular blockade induced by rocuronium or vecuronium. It is administered intravenously as a single bolus injection. It forms complexes by capsuling the neuromuscular blocking agents in plasma, thereby reducing the amounts available for binding to the nicotine receptor in the neuromuscular synapse.
Metabolism and pharmacokinetics
Sugammadex is not metabolized by the liver. Unchanged sugammadex or complex is excreted in the urine.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Peeters P, Passier P, et al, Sugammadex is cleared rapidly and primarily unchanged via renal excretion.
Biopharm Drug Dispos. 2011 Apr;32(3):159-67. |
|
| * | Summary of Product Characteristics | |
| 2. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Bridion.
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Tradenames
Bridion · Sugagelan · Sugammadex 
Bridion · Sugammadex 
Bridion · Sugammadex · Sugammadex elm 
Areversin · Bridion · Sugammadex 
Areversin · Sugammadex 
Bridion · Sugammadex 
Bridion · Sugammadex 
Bridion · Sugammadex 
Bridion · Sugammadex 
Bridion · Sugammadex 
Bridion · Sugammadex 
Bridion · Sugammadex 
Bridion · Sugammadex 
Bridion · Sugammadex · Zenagam 
Bridion · Sugammadex 
Bridion · Sugammadex 
Axonin · Bridion · Sugamadeks · Sugammadex 
Bridion · Sugamadeks 
Bridion · Sugammadex 
Sugamadex · Suggamadex 
Sugammadex