Acute Porphyria Drugs

Monograph

A16AA05 - Carglumic Acid
Not porphyrinogenic
NP

Rationale
Non-Cyp metabolism of carbamoylated aminoacid. No conceivable physiological effects or side effects. Several indications relate to newborn or prepubertal children.
Chemical description
Carbamoyl glutamic acid. Structural analogue to N-acetyl glutamic acid, the physiological activator of hepatic carbamoylfosfate syntetase.
Therapeutic characteristics
Activator of hepatic acetylglutamate syntetase, the initial enzyme in urea biosynthesis. Under conditions of hyperammonemia the levels of ammoniac decreases and those of urea increases.
Hepatic exposure
Significant.
Metabolism and pharmacokinetics
About 30 % of the dose is absorbed giving a plasma concentration of 2-5 ug/ml. Partly metabolized to glutamic acid, and to carbon dioxide eliminated by the lungs.
Similar drugs
Explore alternative drugs in similar therapeutic classes A16A / A16AA or go back.
References
Tradenames

Carbaglu · Carglumaatzuur · Ucedane Carbaglu · Ucedane Acido Carglumico · Carbaglu · Ucedane Carbaglu · Ucedane Acido Carglumico · Carbaglu · Ucedane Carbaglu Carbaglu Carbaglu · Carglumic acid · Ucedane Carbaglu · Cargluminsyre · Ucedane Carbaglu · Ucedane Carbaglu · Kwas kargluminowy · Ucedane Carbaglu Carbaglu · Ucedane Carbaglu · Karglumiinihappo · Ucedane Carbaglu · Ucedane Carbaglu · Ucedane Carbaglu · Ucedane Carbaglu Carbaglu · Ucedane Carbaglu · Ucedane Acide carglumique Acido carglumico Carglumic acid
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