Monograph
C01CA07 - Dobutamine |
Not porphyrinogenic |
NP |
Rationale
Non-CYP metabolism. No data pointing to CYP-interaction. Four lists stating non-porphyrinogenicity.
Chemical description
Therapeutic characteristics
Synthetic catecholamine used in acute heart failure due to its inotropic effects on the heart. Given in infusion 0.25-1 g/l.
Metabolism and pharmacokinetics
Metabolized in tissues and in the liver. Conjugated to glucuronic acid and methylated by COMT. Excreted in urine within six hours as glucuronide conjugates.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
Tradenames
Dobutamine 
Dobutrexviatris 
Dobutamina 
Dobutamin 
Dobutamina 
Dobutrex 
Dobutamine · Dobutrex · Posiject 
Dobutrex 
Dobutamin 
Dobutamin · Dobutamine 
Dobutamin · Dobutrexviatris 
Dobutrex 
Dobutamin 
Dobutamina · Dobutamine 
Dobutamine 
Dobutamin · Dobutamine 
Dobutamin · Dobutrex · Inotop 
Dobutamina 
Dobutamine